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KMID : 0359919930120030488
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Korean Journal of Nephrology
1993 Volume.12 No. 3 p.488 ~ p.494
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Membranous Nephropathy Associated with Small Cell Lung Cancer and Recurrent Multiple Arterial Thromboses in the Lower Extremities
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정윤철
임춘수/주권욱/안규리/한진석/김성권/이정상/임정기/박재형
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Abstract
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We experienced a case of nephrotic syndrome with recurrent multiple arterial thromboses in the lower extremities, late confirmed as membranous nephropathy associated with small cell lung cancer. He was admitted to Seoul National university
Hospital
due
to multiple left lower extremity arterial thromboses 25 days after the development of nephrotic syndrome. Thomboses and subsequent ischimic necrosis progressed in spite of two times of thrombectomy. So we amputated the left leg above knee. The
kidney
biopsy revealed membranous nephropathy without any evidence of systemic causes including malignancy. During the second admission due to the recurrent multiple arterial thromboses of right lower extremity, right lung mass and pleural effusion
appeared in
the simple chest film and chest CT. We confimed small cell lung cancer by fine needle aspiration cytotolgic examination. We emphasize the possibility of the associated hidden carcinoma should be studied thoroughly in the patients with membranous
nephropathy, nephrotic syndrome and recurrnt multiple arterial thromboses and in those who have symptoms and signs hard to explain by membranous nephroathy an dnephrotic syndrome alone.
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KEYWORD
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